Key Product Ingredient Highlights:
Studies have shown probiotics are beneficial in the treatment of digestive disorders such as diarrhoea
and some inflammatory bowel conditions. Some strains of Bifidobacteria and lactobacillus can adhere to
the epithelium and act as colonization barrier by preventing pathogens from adhering to the mucosa.
Probiotics produce inhibitory substances such as bacteriocins, lactic acid and toxic oxygen metabolites. A
growing body of evidence indicates that in particular lactobacilli and bifidobacteria can modulate the
immune system at both the systemic and the mucosal level affecting many cell types (e.g., epithelial cells,
dendritic cells, natural killer cells, etc). Consequently, health benefits induced by probiotics include the
strengthening the intestinal barrier via enhancing tight junction protein structures and down regulating
transcription of genes encoding proinflammatory effectors and up regulating anti-inflammatory cytokines.
Concomitant administration of some strains of probiotics reduces gastrointestinal and genitourinary side
effects of antibiotics according to clinical studies — combination can be safely used together and a
beneficial interaction is likely. Administration of probiotics is often used as a means of restoring this
microflora imbalance. Probiotic induce changes in the GIT microflora specifically by inhibiting the growth
of potentially pathogenic organisms, significantly increasing gastrointestinal population of beneficial
bacteria while simultaneously decreasing population of less health-promoting genera.
Functions in the body include metabolism: influence the metabolism of fatty acids, bile acids, cholesterol
and steroid hormones in the intestinal tract; Digestion: influence colonic blood flow and the secretion of
mucin and pancreatic digestive enzymes. Synthesize the vitamins B1, B2, B3, B6, B12, folic acid, biotin
and Vitamin K; help to lower cholesterol by converting it to a less absorbable form known as coprostanol,
which inhibits its absorption from the intestinal tract; energy: the short chain fatty acids produced by
bifidobacteria are the main source of energy utilized by epithelial cells in the colonic mucosa; help protect
against gastrointestinal infections by adhering to the intestinal mucosa, which prevents pathological
bacteria from adhering, producing an acidic environment, causing activation of macrophages (immune
cells) which suppress pathogenic bacteria. Clinical applications include decreasing flatulence.
Supplementation with B. longum resulted in the production of significantly less hydrogen gas in the
intestines and a corresponding decrease in flatulence.
Lactobacillus acidophilus is one of the most prominent strains of beneficial bacteria that predominantly
reside in the small intestine. They provide a number of beneficial functions and effects such as prevention
of bacterial infections, enhancement of digestion and absorption of nutrients, metabolism of cholesterol,
and a strengthening of the immune system.
The most common probiotic bacteria are lactic acid bacteria such as bifidobacteria and lactobacilli. The
increased presence of these health-promoting bacteria in turn helps to inhibit the growth of other, pathogenic bacteria.
Probiotics are generally thought to:
- Enhance the host’s immune defence system by increasing secretory IgA production, tightening the
mucosal barrier, enhancing lymphocyte cytokine response, enhancing phagocytic activity, and
enhancing intestinal cell mucin production and secretion (to enhance the mucus layer).
- Displace, exclude, or antoagonize pathogenic bacteria from colonizing, by competing for attachment
sites or strengthening the mucosal barrier to normalize intestinal permeability.
- Acidify the colonic pH by producing fermentation products such as short chain fatty acids.
- Transform and promote excretion of toxic substances such as bile acids, and matagenic compounds,
enhance faecal bulk production, which may decrease (speed up) transit time and thereby lower the
colons.
Directions for Use:
Adults: 1 to 2 Capsules per day or as prescribed by your health care practitioner.
To be swallowed with water.
Refrigerate between 2-80C, do not freeze.
If symptoms persist consult your healthcare practitioner.
Keep away from children. Always read the label carefully before use.
